Aquaporin-1-facilitated keratocyte migration in cell culture and in vivo corneal wound healing models
نویسندگان
چکیده
منابع مشابه
Zebrafish keratocyte explants to study collective cell migration and reepithelialization in cutaneous wound healing.
Due to their unique motile properties, fish keratocytes dissociated from explant cultures have long been used to study the mechanisms of single cell migration. However, when explants are established, these cells also move collectively, maintaining many of the features which make individual keratocytes an attractive model to study migration: rapid rates of motility, extensive actin-rich lamellae...
متن کاملEquation-Based Models of Wound Healing and Collective Cell Migration
Wound healing is a physiological process of repair of a tissue that has been structurally damaged. The most common wounds disrupt one of the epithelial tissues that protect the internal and external surfaces of the body and act as barriers against invasion by microorganisms. Such tissues include skin, corneal tissue, and the epithelial lining of the digestive tract (including the mouth and esop...
متن کاملProbiotic Bacteria in Wound Healing; An in-vivo study
Background: Probiotics are food supplements, which benefits the host by improving its intestinal microbial balance. Probiotics are used as diet supplements to prevent diarrhoea and improve lactose tolerance.Objective: The present study deals with isolation of a potent probiotic strain capable of inducing healing properties in rat model.Method: Probiotic VITSAMJ1 was isolated from go...
متن کاملDownregulation of PTEN at corneal wound sites accelerates wound healing through increased cell migration.
PURPOSE The PI3K/Akt pathway is required for cell polarization and migration, whereas the phosphatase and tensin homologue deleted on chromosome 10 (PTEN) has inhibitory effects on the PI3K/Akt pathway. The authors therefore hypothesized that wounding would downregulate PTEN and that this downregulation would enhance wound healing. METHODS In human corneal epithelial (HCE) cell monolayer and ...
متن کاملDelay of corneal epithelial wound healing and induction of keratocyte apoptosis by platelet-activating factor.
PURPOSE To examine the role of the lipid mediator platelet-activating factor (PAF) in epithelial wound healing. METHODS A 7-mm central de-epithelializing wound was produced in rabbit corneas, and the tissue was incubated with 125 nM carbamyl PAF (cPAF), an analogue of PAF. Rabbit corneal epithelial and stromal cells were also cultured in the presence of cPAF. Cell adhesion, proliferation, and...
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ژورنال
عنوان ژورنال: Experimental Eye Research
سال: 2009
ISSN: 0014-4835
DOI: 10.1016/j.exer.2009.03.002